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Can Manning Crack the 49ers' 3-4?

QB Peyton Manning (Stephen Dunn/Getty)

The 49ers run a very vanilla version of the 3-4 defense, but what does that mean? Brad Keller takes a deeper look.

Historically, the 3-4 defense has been a challenge for Peyton Manning and the Colts blocking schemes.  The New England Patriots, San Diego Chargers, and Pittsburgh Steelers have all presented a stiff challenge to Manning at one point, although he has had much better luck against the hybrid 3-4/4-3 defense that the Baltimore Ravens deploy. A key mystery for Manning and the Colts offensive...

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